Chromopyrrolic

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August undefined, 2024

WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 Webchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula …

PIM KINASE INHIBITOR COMPOSITIONS, METHODS, AND USES …

WebMay 13, 2015 · As suggested by our phylogenetic analysis of CPAS genes, identified in our survey of crude eDNA extracts, reductasporine (2) contains an unprecedented TD core structure: a pyrrolinium indolocarbazole core that is … WebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and … easway coaches

2R0G: Chromopyrrolic acid-soaked RebC with bound …

WebJan 1, 2006 · Chromopyrrolic acid is oxidized by six electrons compared to the starting pair of L-tryptophan molecules. RebO is an L-tryptophan oxidase flavoprotein and RebD a … WebJul 3, 2014 · An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu (OAc)2 in conjunction with Mn (OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. WebJan 3, 2024 · Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food industries. … easwebcenter

Evidence for catalytic intermediates involved in generating the ...

细胞色素P450结构与催化机理_王斌.pdf - 原创力文档

WebMar 15, 2009 · HPLC analysis of chromopyrrolic acid (CPA) produced by S. albus J1074 strains containing plasmid pUWL201 (A) and pLinkOD (B). CPA is indicated by filled arrow (retention time 26 min). Download : Download full-size image Figure 3. MS analysis of chromopyrrolic acid (CPA). ESI-MS [M+H] +: m / z = 386.1. WebA pair of genes (vioAB), responsible for the earliest steps in violacein biosynthesis, was functionally equivalent to the homologous pair in the indolocarbazole … easwebclientWebchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula C22H15N3O4 Net Charge 0 Average Mass 385.373 Monoisotopic Mass 385.10626 InChI eas web 方法路径

"WebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45]. " - Chromopyrrolic

Chromopyrrolic

Combinatorial biosynthesis of antitumor indolocarbazole compounds - PNAS

WebJun 6, 2007 · Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Staurosporine isolated from Streptomyces sp. … WebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid. Journal Of The American Chemical Society, 128 (37). 12289-12298 doi:10.1021/ja063898m

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WebMay 20, 2024 · 除以上概述的结构类型外，在深海链霉菌生物碱类化合物的生物合成基因簇中也发现了P450酶基因的踪迹.Ma等[78]在研究一株来自深海的链霉菌Streptomycessp.SCSIO 03032中产生的具有抗菌、抗肿瘤活性的吲哚咔唑类生物碱spiroindimicins的生物合成机制时发现，P450酶编码 ... WebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product …

WebMar 15, 2009 · The resultant strain yielded chromopyrrolic acid that was purified and identified by LC-ESI MA and NMR. The work described in this study may serve as a …

Webring rearrangement from indole-3-pyruvic acid and NH4+ by the action of chromopyrrolic acid synthase (VioB or StaD) (Asamizu et al. 2007; Hirano et al. 2008). C. violaceum genome analysis showed that the genes trpA–F and pabA–B encode the anthranilate synthase in the tryptophan pathway in the conversion of chorismate to anthranilate (see ... WebAs a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme. As a reactant in the Biginelli-like scaffold syntheses. Packaging. 250, 500 mg. 1, 5 g in poly bottle. Linkage. α-Keto analogue of tryptophan. Safety Information. Pictograms. GHS07. Signal Word. Warning.

WebApr 5, 2012 · 4EIP, 4EIQ. PubMed Abstract: The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products …

Webchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ... cummins isx15 oil cooler replacementChromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid. easweb端WebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol. Biochem. 2003, 67, 127-138), which proceeds by an unusual C-C bond coupling. Additionally, because CPA is immobilized by a hydrogen-bonding … easweat cyclingWebJun 12, 2014 · This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. The structure of chromopyrrolic acid was closely related to that of violacein and deoxyviolacein. The pyrrole dicarboxylic acid moiety of chromopyrrolic … cummins isx15 oil panWebJun 29, 2024 · 细胞色素P450结构与催化机理_王斌.pdf,闷讹缄纸酿养秩疆悸赊邯碧匆倍七软桶靠赌银钦踌肢箭甲楔逗聊俱挽顽婉梗冯薄佐娩充钡摸乏渣乙侍獭炙失奉械迄砸志球巧峰井告青殃颁惧长币蝗鸥造试尺簇君斩糊伸棍滦祝格撇瞒骇前赠言眠束乒愧 ... cummins isx15 oil in coolantWebAug 19, 2007 · 2R0C, 2R0G, 2R0P. PubMed Abstract: The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one … cummins isx 15 oil filterWebDec 29, 2004 · In agreement with this hypothesis, no chlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 8 ) and arcyriaflavin … cummins isx 15 motor for sale