Cisplatin efficacy

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August undefined, 2024

WebSep 27, 2016 · PURPOSE Paclitaxel, ifosfamide, and cisplatin (TIP) achieved complete responses (CRs) in two thirds of patients with advanced germ cell tumors (GCTs) who relapsed after first-line chemotherapy with cisplatin and etoposide with or without bleomycin. We tested the efficacy of first-line TIP in patients with intermediate- or poor … WebThis enhanced drug efficacy could be attributable to Rev7’s ability to promote cisplatin resistance via the TLS DNA damage tolerance pathway and/or its regulation of DSB repair pathway choice. Indeed, Rev7 inactivation enhances cisplatin efficacy beyond that seen with disruption of other Pol ζ-components ( 5 ), suggesting that the effects of ...

Cisplatin in cancer therapy: molecular mechanisms of action

WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder cancer. It is also used in combination with other agents in … WebSep 20, 2024 · Efficacy was evaluated in two multicenter open-label, randomized controlled trials in pediatric patients undergoing treatment with cisplatin-based chemotherapy for … dewalt reciprocating saw sale

Sodium Thiosulfate for Protection from Cisplatin-Induced …

WebMar 17, 2024 · Cisplatin DNA-adduct positivity in primary tumors increased upon OMO-1 treatment in a dose-dependent manner, being significantly higher with cisplatin + 12.5 … WebThe dose of cisplatin was reduced in 26 of 82 patients (31.7%) in the EP arm and in 25 of 82 patients (30.5%) in the IP arm. The mean (range) DI of cisplatin was 21.9 (14.3-26.8) mg/m 2 /wk in the EP arm and 13.6 (9.9 … WebCisplatin is a widely used cytotoxic agent approved in the treatment of bladder, ovarian, testicular, cervical, head and neck, and nonsmall cell lung cancer [ 1 – 3 ]. Cisplatin was first documented in 1847 by M. Peyrone, and it was approved by FDA for a variety of cancers in 1978. dewalt reciprocating saws

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

Efficacy and safety of weekly versus triweekly cisplatin... : Medicine

WebJun 13, 2024 · Cisplatin was the first platinum compound to gain approval by the US Food and Drug Administration (FDA), in 1978. Its mechanism of action is through its ability to bind to DNA, via purine base crosslinking, … church of england npq programmeWebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive … church of england norwich

"WebFeb 15, 2024 · Cisplatin plus anti-PD-1 antibody enhanced treatment efficacy in advanced esophageal squamous cell carcinoma Authors Wu Lin 1 2 , Jiong Qian 3 , Haohao Wang 1 , Ling Ren 2 , Yan Yang 1 , Chuanzhi Chen 1 , Xiangliu Chen 1 , Yingying Huang 1 , Jin Liu 1 , Nong Xu 3 , Lisong Teng 1 Affiliations " - Cisplatin efficacy

Cisplatin efficacy

Efficacy and toxicity of three concurrent chemoradiotherapy ... : …

WebMar 28, 2024 · Approximately two-thirds of patients with PDAC are diagnosed at a metastatic stage. 5 In this setting, the treatment relies on systemic chemotherapy, but options are limited. Following more than 15 years of use of gemcitabine alone as standard, the FOLFIRINOX (5-fluorouracil administered as leucovorin and 5-fluorouracil (LV5FU2), … WebAug 8, 2024 · Background: Cisplatin is one of the frontline anticancer agents. However, development of cisplatin-resistance limits the therapeutic efficacy of cisplatin-based …

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WebOct 1, 2024 · Enhancement of cisplatin efficacy by lipid-CaO 2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment. Hypoxia, acidosis and high … WebJun 11, 2024 · PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review (BICR) will be presented.

WebDec 30, 2024 · Another large cohort study by Zhu et al [ 21] reported that weekly cisplatin was associated with ... WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus …

WebOct 5, 2014 · Cisplatin is cleared by the kidney by both glomerular filtration and tubular secretion (Yao, Panichpisal et al., 2007; Ishida, Lee et al., 2002) Cisplatin … WebThe efficacy of cisplatin must be improved for the treatment of UTUC because most patients with UTUC are older and may have renal insufficiency. The inadequate dose of cisplatin consequently leading to a poor outcome is a clinical challenge.

WebApr 14, 2024 · This overall positive outlook is marred by the development of resistance or reduced efficacy of the drug combinations, but the underlying mechanisms are somewhat unclear. It is interesting to note that cancer cells quickly adapt and evade most therapies by activating autophagy, a catabolic process designed to recycle damaged cellular …

WebJul 3, 2024 · These include blockade of cisplatin entry into the cochlear fluid or hair cells. Further, antioxidants are among the most extensively studied agents due to the importance of ROS in ototoxicity. However, a concern exists that the chemotherapeutic efficacy of cisplatin may be reduced (Block et al., 2009). Reductions in inflammatory cytokine ... church of england on divorceWebCisplatin : an old drug with a newfound efficacy -- from mechanisms of action to cytotoxicity Although cisplatin has been used for a long time, only recently its exact mechanism of action has been better defined. church of england official bibleWebApr 11, 2024 · Importantly, inhibition of STAT3 signaling significantly attenuated MB tumor growth in subcutaneous and intracranial orthotopic xenografts, increased the sensitivity of MB tumors to cisplatin, and improved the survival of … dewalt reciprocating saw parts diagramWebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … church of england numberWebThis randomized clinical trial assesses whether etoposide plus cisplatin or irinotecan plus cisplatin is a more effective treatment regimen in terms of overall [Skip to Navigation] ... One interim analysis for efficacy and … church of england officialsWebApr 5, 2024 · Concurrent chemoradiotherapy with 3-weekly cisplatin 100 mg/m 2 has been the standard of care for locoregionally advanced head and neck cancer (LA-HNC) with level I evidence. While the outcomes in terms of efficacy have been well established, the toxicity profile, compliance, and real-world applicability has been an area of ongoing concern for … dewalt recip safety bootsWebAn "accidental" discovery leads to cisplatin.Because platinum was thought to have no biological activity, Dr. Rosenberg and his colleagues put platinum electrodes into a solution containing the common laboratory bacteria E. … church of england online faculty system