Cisplatin electrolyte abnormalities

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WebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side … WebJun 10, 2024 · However, cisplatin is known to cause a variety of adverse effects (such as nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral neuropathy, hepatotoxicity, and retinopathy) than other chemotherapy regimens. Diarrhea, pancreatitis, seizures, and respiratory failure have also been reported.

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WebJul 28, 2024 · Electrolyte Abnormalities: This medication can affect the normal levels of electrolytes (potassium, magnesium, calcium, etc.) in your body. Your levels will be monitored using blood tests. If your levels become too low, your care team may prescribe specific electrolytes to be given by IV or taken by mouth. Webcisplatin, and was severe in 20%. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. Withhold PORTRAZZA for Grade 3 or 4 electrolyte abnormalities. Replete electrolytes as medically appropriate. (5.2) diabetes mellitus and osteoporosis

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WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium … WebFrequency not known. Alopecia; appetite decreased; asthenia; autonomic dysfunction; cardiac disorder; cerebrovascular insufficiency; deafness; dehydration; diarrhoea; … WebOct 19, 2024 · In the literature, cisplatin-associated electrolyte abnormalities are poorly described, but hypomagnesemia occurs in 14–94% of children [3, 4, 36, 38, 39]. CNS … cindy chrisman

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WebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic … Web5.3 Electrolyte and Metabolic Abnormalities In addition to causing hyperkalemia, spironolactone tablets can cause hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, and hyperglycemia. Asymptomatic hyperuricemia can occur and rarely gout is precipitated. Monitor serum electrolytes, uric acid and blood glucose … diabetes mellitus and pancreasWebDec 29, 2024 · Anticancer agents associated with electrolyte abnormalities included cisplatin, carboplatin, oxaliplatin, vincristine, vinblastine, cyclophosphamide and ifosfamide. CKD, chronic kidney disease. Open in new tab Incidence of hyponatremia and other electrolyte abnormalities diabetes mellitus and the risk of cancer

"WebJun 24, 2024 · The most common electrolyte abnormalities were hypomagnesemia (88.9%, Vancouver) and hypophosphatemia (24.2%, Mexico City). ... Since nephrotoxicity is commonly found in cisplatin-treated children, electrolyte abnormalities can also help in understanding a patient’s kidney function, especially in the early stage of cisplatin … " - Cisplatin electrolyte abnormalities

Cisplatin electrolyte abnormalities

An overview of diagnosis and management of drug‐induced

WebSep 27, 2024 · Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes. WebDec 16, 2024 · However, cisplatin-induced nephrotoxicity is a major dose-limiting factor and a significant adverse event. Mannitol is used to reduce cisplatin-induced nephrotoxicity, which is controversial. ... Diuretics contribute to electrolyte disorders, often promoting the excretion of electrolytes into urine by the kidneys. In this meta …

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WebHypomagnesemia occurred in 83% of patients receiving PORTRAZZA in combination with gemcitabine and cisplatin, and was severe in 20% of patients. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. WebSep 15, 2024 · Deafness after the initial dose of cisplatin (cisplatin injection) has been reported rarely. Ototoxic effects may be more severe in children receiving cisplatin …

WebManufacturer advises cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting. ... Side-effects Side-effects For cisplatin. Common or very common. Anaemia; arrhythmias; bone marrow failure; electrolyte imbalance; extravasation necrosis; fever; leucopenia; nephrotoxicity (dose-related and ... WebSep 18, 2024 · NCBI Bookshelf

Web• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... WebApr 15, 2016 · 3. Platinum-containing drugs (cisplatin, carboplatin and oxaliplatin) Cisplatin, carboplatin and oxaliplatin are platinum-containing anticancer drugs targeting solid cancers, such as head and neck cancer, lung cancer, and cervical cancer (Ali et al., 2013).The use of these drugs has been associated with a number of electrolyte …

WebApr 12, 2024 · In cancer patients, electrolyte disorders are frequent due to tubular functional abnormalities related to chemotherapeutic drugs, the TLS and the impaired secretion of antidiuretic hormone ... As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced ...

WebJun 8, 2024 · Acute overdosage with cisplatin injection may result in renal failure, hepatic failure, hearing loss, ocular toxicity, myelosuppression, nausea and vomiting, and neuritis. cindy christian long hairWebNational Center for Biotechnology Information cindy choubane instagramWebMay 19, 2024 · Electrolyte disorders are also related to cisplatin-induced DNA damage of thiazide-sensitive sodium-chloride co-transporter genes and to the apoptosis of distal tubule cells . Cisplatin treatment … cindy chowdhuryWebCisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken ... Hypomagnesemia is the most common electrolyte abnormality related to chronic alcohol abuse and affects as many as 30% of alcohol-dependent patients. 148, ... cindy chow disneyWebNational Center for Biotechnology Information cindy christo brownWebSep 15, 2024 · Cisplatin is administered parenterally and is available in 50 and 100 mg vials in generic forms and under the brand name Platinol. The recommended dose varies by indication, tumor type, patient age and body weight. Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and ... diabetes mellitus active learning templateWebMay 1, 2024 · The most common diagnoses were central nervous system tumors (58 [36%]), neuroblastoma (43 [27%]), and osteosarcoma (33 [21%]). Acute kidney injury (by serum creatinine level increase) occurred in 48 of 159 patients (30%) at early cisplatin infusions and 23 of 143 patients (16%) at late cisplatin infusions. cindy christian realtor murfreesboro tn