Web100002070 - Gene Resultirf4a interferon regulatory factor 4a [ (zebrafish)] Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding … WebCcr9a and Irf4a, two indispensable factors in T lymphopoiesis, were the direct targets of Ikzf1 and were absent in the ikzf1 mutants. Genetic deletion of either ccr9a or irf4a in the corresponding mutant embryos led to obvious T cell development deficiency, which was mainly caused by disrupted thymic migration of HSPCs.
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