WebJun 6, 2024 · However, when dysregulated, SMC phenotype switching contributes to cardiovascular disorders, including atherosclerosis, in-stent restenosis, and coronary allograft vasculopathy. Whereas substantial advances have been made in understanding SMC phenotype switching, we have yet to successfully target SMC phenotype for … WebOct 8, 2024 · Therapy-induced phenotype switching often refers to a bidirectional phenomenon in which cells switch between a drug-sensitive and a stem-like drug-resilient state. However, this model is likely...
An update on the phenotypic switching of vascular smooth ... - Springe…
WebAug 20, 2010 · Yet if phenotype-switching is reversible, then perhaps the greater majority of melanoma cells have the potential to adopt a ‘stem cell-like’ phenotype, accounting for the high proportion of cells able to seed tumours in severely immunocompromised mice (Quintana et al., 2008). On the other hand, if, as for normal melanocyte stem cells, there ... WebOct 1, 2012 · The pathogen Staphylococcus aureus undergoes phenotype switching in vivo from its normal colony phenotype (NCP) to a slow-growing, antibiotic-resistant small-colony-variant (SCV) phenotype that is associated with persistence in host cells and tissues. However, it is not clear whether phenotype switching is the result of a constitutive … st joseph catholic church erie mi
Phenotypic switching - Wikipedia
WebAug 3, 2012 · INTRODUCTION. Phenotype switching from a normal to a slow-growing or dormant phenotype is a widely employed bet-hedging strategy to insure bacteria against environmental conditions that might otherwise eradicate the entire population (3, 17, 19, 37).Staphylococcus aureus is responsible for a raft of superficial and invasive infections, … WebSep 20, 2024 · “Phenotype switching” has been proposed as a major contributor to melanoma tumor heterogeneity, a key determinant of the emergence of therapy-resistant cells, and a major cause of treatment failure and tumor recurrence. WebSep 30, 2024 · Timely VSMC phenotype switching requires a set of coordinated actions of molecular and cellular mediators to result in an expansive remodeling of collaterals that … st joseph catholic church fort stockton tx